Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1425-1427

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Simple and Sensitive RP-HPLC Method for Estimation of Trandolapril in Bulk and Tablet Dosage Forms



Address:   V. Bhaskara Raju1 and A. Lakshmana Rao2*
1Sri Vasavi Institute of Pharmaceutical Sciences, Tadepalligudem- 534 101, A.P., India.
2V.V. Institute of Pharmaceutical Sciences, Gudlavalleru- 521 356, A.P., India.
*Corresponding Author
DOI No:

ABSTRACT:
An accurate and precise HPLC method was developed for the determination of trandolapril. Separation of the drug was achieved on a reverse phase C18 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 35:65 v/v. The flow rate was 0.8 ml/min and the detection wavelength was 210 nm. The linearity was observed in the range of 20-60 µg/ml with a correlation coefficient of 0.999. The proposed method was validated for its linearity, accuracy, precision and robustness. This method can be employed for routine quality control analysis of trandolapril in tablet dosage forms.
KEYWORDS:
Trandolapril, Estimation, RP-HPLC, Validation, Tablets.
Cite:
V. Bhaskara Raju, A. Lakshmana Rao. A Simple and Sensitive RP-HPLC Method for Estimation of Trandolapril in Bulk and Tablet Dosage Forms. Asian J. Research Chem. 4(9): Sept, 2011; Page 1425-1427.
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