Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1440-1443

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric Method for Simultaneous Estimation of Desloratadine and Pseudoephedrine Hydrochloride from Tablets and Dissolution Media



Address:   Sachin U. Kushare, Mahantesh Mali, Atul Phatak* and Praveen D. Chaudhari
P. E. Society’s Modern College of Pharmacy, Nigdi, Pune 411 044, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
The simple, selective, rapid, precise and economical spectrophotometric method has been developed for simultaneous estimation of Desloratadine and Pseudoephedrine Hydrochloride, from two components solid dosage forms and dissolution media. Dissolution media 0.1N Hydrochloride acid and 0.1M Potassium Phosphate Buffer PH 7.5 was used. The simultaneous equation method involves the measurement of absorbance at two wavelength 281.5 nm (?max of Desloratadine) and 256.5 nm (?max of Pseudoephedrine Hydrochloride) in 0.1N Hydrochloride acid. 241.5 nm (?max of Desloratadine) and 256.5 nm (?max of Pseudoephedrine Hydrochloride) in 0.1M Potassium Phosphate Buffer (PH 7.5). The linearity lies between 2.5-25 µg/ml for Desloratadine and 120-960 µg/ml for Pseudoephedrine Hydrochloride in both media. The developed method was validated in terms of accuracy, precision, Linearity, Limit of detection, Limit of quantitation. The method showed good reproducibility and recovery with % RSD less than 1.5. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Desloratadine and Pseudoephedrine Hydrochloride from Tablets and dissolution media.
KEYWORDS:
Desloratadine, Pseudoephedrine Hydrochloride, Spectrophotometry, Simultaneous equation method.
Cite:
Sachin U. Kushare, Mahantesh Mali, Atul Phatak, Praveen D. Chaudhari. Spectrophotometric Method for Simultaneous Estimation of Desloratadine and Pseudoephedrine Hydrochloride from Tablets and Dissolution Media. Asian J. Research Chem. 4(9): Sept, 2011; Page 1440-1443.
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