Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1361-1365

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Various Methods for Synthesis of Purine Analogues

Address:   Sachan Dinesh*, Pandeya S.N. and Pathak A.K.
Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow.
*Corresponding Author

The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to speci?c ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with af?nities comparable to that of the natural ligand, and several also inhibit microbial growth.
Purines, Synthesis.
Sachan Dinesh, Pandeya S.N., Pathak A.K. Various Methods for Synthesis of Purine Analogues. Asian J. Research Chem. 4(9): Sept, 2011; Page 1361-1365.
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