Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1453-1459

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Antibacterial, Anthelmintic, Analgesic and Anti-Inflammatory Activity of Conventional and Microwave Assisted Synthesized 3-(Substituted)-2-Phenylquinazolin-4(3h)-One



Address:   Subal Debnath* and S.Y. Manjunath
Department of Pharmaceutical Chemistry, Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Mdl: Kondapak, Dist. Medak, Siddipet, Andhra Pradesh – 502 277, India.
*Corresponding Author
DOI No:

ABSTRACT:
The present research work were aimed to synthesize a series of various substituted quinazolinone containing 3-(Substituted)-2-phenylquinazolin-4(3H)-one. The compound 2-Phenyl-4H-3,1-benzoxazin-4-one, I were prepared by treating anthranilic acid with benzoyl chloride in pyridine. Synthesis of 3-Amino-2-phenylquinazolin-4(3H)-one, II carried out by reacting, I with hydrazine hydrate in ethanol. The compound 2-{[(4-Oxo-2-phenylquinazolin-3(4H)-yl)-amino]carbonyl}benzoic acid, III obtained by reacting II with phthalic anhydride in ethanol. Synthesis of 2-Phenyl-3- [{-(4-substituted)-phenylmethylene}-amino]-quinazolin-4(3H)-one, IV(a-b) were done by reacting II with 4-Substituted benzaldehyde in glacial acetic acid. Synthesis of N-(4-Oxo-2-phenylquinazolin-3(4H)-yl)benzamide, V were done by reacting II with benzoyl chloride in pyridine. Finally, 3-[3-(2,4-Dichlorophenoxy)-3-(4-substituted phenyl)-2-oxoazetidin-1-yl]-2-phenylquinazolin-4(3H)-one, VI(a-b) were synthesized by reacting IV(a-b) with 2,4-Dichlorophenoxyacetic acid and thionyl chloride in benzene. These derivatives were prepared by microwave as well as conventional method. Structure of the compounds has been established by means of IR, 1H-NMR and MS. All the compounds were evaluated for antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Most of the compounds showed significant antibacterial activities when compared with the standard drug ciprofloxacin at the concentration of 500 µg/ml and 250 µg/ml. In this research work, in vitro anthelmintic activity of 3-(Substituted)-2-phenylquinazolin-4(3H)-one carried out in comparison with piperazine citrate. These newly synthesized quinazolinone derivatives showed paralysis and followed by death at concentration of 10 mg/ml for the screening of anthelmintic activity. These derivatives also screened for analgesic and anti-inflammatory activity. The results showed that synthesized compound having moderate analgesic and anti-inflammatory activity.
KEYWORDS:
Quinazolin-4(3H)-one, 4H-3,1-Benzoxazin-4-one, antibacterial, anthelmintic, analgesic and anti-inflammatory activity.
Cite:
Subal Debnath, S.Y. Manjunath. Antibacterial, Anthelmintic, Analgesic and Anti-Inflammatory Activity of Conventional and Microwave Assisted Synthesized 3-(Substituted)-2-Phenylquinazolin-4(3h)-One. Asian J. Research Chem. 4(9): Sept, 2011; Page 1453-1459.
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