Journal :   Asian Journal of Research in Chemistry

Volume No. :   4

Issue No. :  9

Year :  2011

Pages :   1388-1392

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Extractive Spectrophotometric Determination of Mianserin Hydrochloride by Acid-Dye Complexation Method in Pure and In Pharmaceutical Preparations



Address:   Rabie S. Farag1, Mahamoud S. Afifi1 and Mahmoud M. Abd-Rabow2*
1Prof. of Inorganic Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
2Forensic Chemist, Chemical Laboratory of Medico-Legal Department, Ministry of Justice, Cairo, Egypt,
*Corresponding Author
DOI No:

ABSTRACT:
A simple and sensitive extractive spectrophometric method has been described for the assay of Mianserin hydrochloride (M-HCl) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-association complex of Mianserin hydrochloride (M-HCl) with Picric acid (PA), Chlorophenol red (ClPR), Bromthymol blue (BrTB), Bromcresol purple (BrCP) reagents. The extracted complexes showed absorbance maxima at optimum wavelength using visible spectrophotometer. Beer’s law is obeyed in the concentration range of 1-42 µg/mL. Correlation coefficient was found to be = 0.9985. In addition we have determined the molar absorptivity, Sandell sensitivity and the optimum conditions for quantitative analysis of the investigated drugs.
KEYWORDS:
Spectrophotometry, Mianserin hydrochloride, chloroform, pharmaceutical analysis, Ion-association complex.
Cite:
Rabie S. Farag, Mahamoud S. Afifi, Mahmoud M. Abd-Rabow. Extractive Spectrophotometric Determination of Mianserin Hydrochloride by Acid-Dye Complexation Method in Pure and In Pharmaceutical Preparations. Asian J. Research Chem. 4(9): Sept, 2011; Page 1388-1392.
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