Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  1

Year :  2012

Pages :   108-115

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Stable and pH-Responsive Core–Shell Nanoparticles Based on HEC and PMAA Networks via Template Copolymerization

Address:   Sudhakara Reddy Pondugula1*, Nataraj Narra2, Sunil J.3, Srinivas B.4
1Dr. Reddys Laboratories, Bachupally, Hyderabad, A.P, India.
2Mother Teresa College of Pharmaceutical Sciences, NFC Nagar, Ghatkesar, India
3Anurag Pharmacy College, Kodad, AP, India.
4RS I Laboratories, Hyderabad, AP, India
Corresponding author

Taking advantage of the specific hydrogen bonding interactions, stable and pH-responsive core–shell nanoparticles based on hydroxyethyl cellulose (HEC) and polymethacrylic acid (PMAA) networks, with a size ranging from 190 to 250 nm, can be efficiently prepared via facile one-step co-polymerization of methacrylic acid (MAA) and N,N'-methylenebisacrylamide (MBA) on HEC template in water. Using dynamic light scattering, electrophoretic light scattering, fluorescence spectrometry, thermo-gravimetric analysis, TEM, and AFM observations, the influence of crosslinker MBA as well as the reaction parameters were studied. The results show that after the introduction of crosslinker MBA, the nanoparticles became less compact; their size exhibited a smaller pH sensitivity, and their stability against pH value was improved greatly. Furthermore, the size, structure, and pH response of the nanoparticles can be adjusted via varying the reaction parameters: nanoparticles of smaller size, more compact structure, and higher swelling capacity were produced as pH value of the reaction medium increased or the HEC/MAA ratio decreased; while nanoparticles of smaller size, less compact structure and smaller swelling capacity were produced as the total feeding concentration increased.
Core, shell nanoparticles, Synthesis , Template polymerization , pH sensitivity , Crosslinking.
Sudhakara Reddy Pondugula, Nataraj Narra, Sunil J., Srinivas B.. Stable and pH-Responsive Core–Shell Nanoparticles Based on HEC and PMAA Networks via Template Copolymerization. Asian J. Research Chem. 5(1): January 2012; Page 108-115.
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