Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   1293-1299

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Novel Synthesis and Biological Evaluation of some New Bipyrazolyl Benzenesulfonamides as possible Antimicrobial and Chemotherapeutic Agents



Address:   Dilesh Indorkar*, O.P. Chourasia and S.N. Limaye
Department of Chemistry, Dr. H.S. Gour Central University, Sagar (M.P.) 470 003
*Corresponding Author
DOI No:

ABSTRACT:
A series of functionalized bipyrazoles, fused bipyrazoles and other related heterocyclic systems have been synthesized.The key intermediate bipyrazoles have been prepared by cyclocondensation of the appropriate chalcone with4-hydrazinobenzenesulfonamide hydrochloride. The chemistry of the reactions employed in the synthesis of the target compounds together with their chemical behaviour, are discussed and the structures of the newly synthesized compounds have been confirmed by the IR and 1H and 13C NMR spectral data. All the synthesized compounds show weak anticancer activity and weak antimicrobial and antifungal activity against some bacteria and fungi.
KEYWORDS:
Pyrazoles, bipyrazoles, bipyrazole benzensulfonamides, thiazolidines.
Cite:
Dilesh Indorkar, O.P. Chourasia, S.N. Limaye. Novel Synthesis and Biological Evaluation of some New Bipyrazolyl Benzenesulfonamides as possible Antimicrobial and Chemotherapeutic Agents. Asian J. Research Chem. 5(10): October, 2012; Page 1293-1299.
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