Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   1309-1319

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Nitro-Imidazole Derivatives an Unique Class for Diverse Biological Activity: A Review

Address:   C.P. Meher*, S.P. Sethy, A.M. Rao
Department of Pharmaceutical Chemistry, Maheswara Institute of Pharmacy, Patancheru, Hyderabad.
*Corresponding Author

Imidazole is one of the important heterocyclic compound in the aromatic world of medicinal chemistry. It is also a important constituent of several natural products including purine, histidine and nuclic acid. But substitution of nitro group in the imidazole or the nitroimidazole enhances the solubility and bioavailability parameter of proposed poorly soluble lead molecule. The application of these nitroimidazole containing drugs has widened in various simple and complex diseases. Nitroimidazole derivative are widely used as the anaerobic anti bacterial, antiprotozoal, antifungal, anti HIV agents, radiosensitizers, hypoxic marker etc. Substitution of the nitro group on the different position (2,4,5) of imidazole show same physical properties but their derivative show variable pharmacological activity. The present review is concerned with the comparative work reported, their chemistry and biological activities of 2-nitroimidazole, 4- nitroimidazole and 5- nitroimidazole derivatives during the past years.
Nitro imidazole, antibacterial, antifungal, antihistamine, antiparasitic, antiamoebic, antoprotozoal, hypoxic marker.
C.P. Meher, S.P. Sethy, A.M. Rao. Nitro-Imidazole Derivatives an Unique Class for Diverse Biological Activity: A Review. Asian J. Research Chem. 5(10): October, 2012; Page 1309-1319.
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