Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   1234-1237

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of Formazan Derivatives



Address:   Pratap Y. Pawar*, Sandhya N. Bahir, Balasaheb Y. Mane
P.D.V.V.P.F’s College of Pharmacy, Vilad ghat, Ahmednagar, Maharashtra, 414111.
*Corresponding Author
DOI No:

ABSTRACT:
In these study, a series of N-(substituted phenylimino)-N'-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamidine (3a-3j) were synthesized from corresponding Schiff base of thiadiazole which was coupled with various aryl diazonium chloride in pyridine produced N-(substituted phenylimino)-N'-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamidine (3a-3j). The structures of the synthesized compounds were determined by IR, 1HNMR. The compounds synthesized were screened for anticonvulsant and neurotoxicity activity. Some of the synthesized compounds exhibited prominent anticonvulsant activity.
KEYWORDS:
Formazans, Thiadiazole, Anticonvulsant activity, Neurotoxicity study.
Cite:
Pratap Y. Pawar, Sandhya N. Bahir, Balasaheb Y. Mane. Synthesis and Biological Evaluation of Formazan Derivatives. Asian J. Research Chem. 5(10): October, 2012; Page 1234-1237.
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