Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  10

Year :  2012

Pages :   1251-1254

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Anti-infective Studies of Some Novel Pyrazoline Derivatives



Address:   S. M. Hipparagi1*, M. D. Bhanushali2, S. A. Patil3, N. S. Desai2
1Department of Pharmaceutical Chemistry, KLE University’s, College of Pharmacy, Rajajinagar, Bangalore-40.
2Department of Pharmaceutical Chemistry, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
3Department of Pharmacognosy, Maratha Mandal’s College of Pharmacy, Belgaum. 590 016
*Corresponding Author
DOI No:

ABSTRACT:
In the present study a new series of 3, 5-diaryl-1-phenyl-2-pyrazoline were synthesized. Chalcones were synthesized by treating various substituted acetophenone with different substituted aromatic aldehydes in the presence of ethanol and sodium hydroxide solution. The pyrazoline derivatives were synthesized by cyclocondensation of chalcones with phenyl hydrazine. The structures of the synthesized compound have been established on the basis of IR and 1HNMR data. The compounds were evaluated in-vitro for their antimicrobial and anti-tubercular activities.
KEYWORDS:
Chalcones, Pyrazoline, Antimicrobial, Anti-tubercular.
Cite:
S. M. Hipparagi, M. D. Bhanushali, S. A. Patil, N. S. Desai. Synthesis and Anti-infective Studies of Some Novel Pyrazoline Derivatives. Asian J. Research Chem. 5(10): October, 2012; Page 1251-1254.
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