Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  11

Year :  2012

Pages :   1346-1349

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Levosulpiride and Pantoprazole in Capsule Dosage Form



Address:   Gunjansinh Parmar*, Khushbu Naik, Renu Chauhan, Shailesh Shah, Dinesh Shah
Department of Quality Assurance, Maliba Pharmacy College, Bardoli, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
The use of first order derivative spectrophotometry allows simultaneous determination of levosulpiride and pantoprazole in fixed dose combination products. The wavelengths 252.5 nm and 291.0 nm of first derivative spectrum were selected for the estimation of levosulpiride and pantoprazole, respectively without mutual interference. The method was linear in the concentration range 25-125 µg/ml and 5-25 µg/ml for levosulpiride and pantoprazole, respectively. Validation studies confirmed the accuracy and precision of the proposed method. The result of the formulation analysis shows that the proposed method can be successfully used for the simultaneous estimation of both the drugs in their combined capsule dosage form.
KEYWORDS:
Levosulpiride, Pantoprazole, Ultra-violet spectrophotometry, Derivative spectrophotometry, Zero crossing point.
Cite:
Gunjansinh Parmar, Khushbu Naik, Renu Chauhan, Shailesh Shah, Dinesh Shah. Development and Validation of Derivative Spectrophotometric Method for Simultaneous Estimation of Levosulpiride and Pantoprazole in Capsule Dosage Form. Asian J. Research Chem. 5(11): Nov., 2012; Page 1346-1349.
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