Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1476-1478

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Determination of Rizatriptan by Visible Spectrophotometry

Address:   C.S.P.Sastry1*, U. Viplava Prasad1, T.S. Reddy2, M.L.N. Acharyulu3
1Department of Organic Chemistry, Foods, Drugs and Water, School of Chemistry, Andhra University, Visakhapatnam –530 003, India.
2DLR College (Degree and P.G Courses),Gollalamamidada, E.G. Dtt, A.P, 533344
3VITAM College of Engg, Mindivani Palem, Ananadapuram Mandal,Visakhapatnam,531173,
*Corresponding Author

Two simple and sensitive visible spectrophotometric methods (M1,M2) are developed for estimation of Rizatriptan (RZT) in bulk and dosage forms. They are based on the formation of colored species with Sodium Nitro prusside-Acetaldehyde (SNP-ACD, Method M1) and Cobalt thiocyanate (CTC, Method M2) reagents exhibiting maximum absorption at 560 nm and 635 nm respectively. Methods M1, M2 obeyed Beer’s law limits in the range of 0.5-2.5?g/ml(M1) and 0.5-2.5?g/ml(M2) respectively and are statistically validated. The proposed methods are selective, simple and economical for the quantitative determination of Rizatriptan.
spectrophotometriy, Rizatriptan(RZT),Cobaltthiocyanate(CTC), SodiumNitroprusside-acetaldehyde (SNP-ACD).
C.S.P.Sastry, U. Viplava Prasad, T.S. Reddy, M.L.N. Acharyulu. Determination of Rizatriptan by Visible Spectrophotometry. Asian J. Research Chem. 5(12): Dec., 2012; Page 1476-1478.
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