Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1482-1502

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Chemistry and Therapeutic Review of Pyrazole



Address:   Biplab De1, Sandip Sen2*, T.S. Easwari2
1Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala-799005
2IIMT College of Medical Sciences, Department of Pharmacy, O-Pocket, Ganganagar, Meerut-250001
*Corresponding Author
DOI No:

ABSTRACT:
Pyrazole is a five membered heterocyclic compound.1, 4-Diketones are found to be good synthons for the synthesis of pyrazole. On the based of the literature it was found that good yield can be achieved by chemoselective and regioselective synthesis. Pyrazole under goes ellectrophillic substitution but nucleophillic substitution is rare one. This interesting group of compound has diverse biological activities- antimicrobial, anticancer, cytitoxicity, analgesic, anti-inflammatory, CNS activity like antiepileptic, antidepressant, antihypertensive activity etc. In the present review our main interest is to emphasize the various synthetic approaches and chemistry reported by researchers on pyrazole for their various. pharmacological activities.
KEYWORDS:
Pyrazole, 1,4-Diketones, Biological activity.
Cite:
Biplab De, Sandip Sen, T.S. Easwari. Chemistry and Therapeutic Review of Pyrazole. Asian J. Research Chem. 5(12): Dec., 2012; Page 1482-1502.
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