Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  12

Year :  2012

Pages :   1448-1451

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of First Order UV-Spectrophotometric Method for Simultaneous Estimation of Tolperisone Hydrochloride and Diclofenac Sodium in Combined Tablet Dosage Forms



Address:   Bhavarth Desai*, Rishet Shukla, Shailesh Shah, Renu Chauhan, Dinesh Shah
Department of Quality Assurance, Maliba Pharmacy College, Bardoli - 394350, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, sensitive, precise and specific first order UV spectrophotometric method for simultaneous estimation of tolperisone hydrochloride and diclofenac sodium in bulk and combined tablet dosage form has been developed using distilled water as a solvent. The absorbances were measured at zero crossing point (ZCP) of tolperisone hydrochloride and diclofenac sodium at 261 nm and 276 nm, respectively. The linearity ranges for tolperisone hydrochloride and diclofenac sodium were 6-21 µg/ml and 2-7 µg/ml respectively. The accuracy of the method was assessed by recovery studies and was found to be 100.43 ± 0.22% and 100.48 ± 0.14% for tolperisone hydrochloride and diclofenac sodium respectively. Results of marketed formulation shows that this method can be applied successfully to marketed formulation. The method is simple, accurate and rapid; requiring no preliminary separation and can therefore be used for routine simultaneous analysis of both drugs.
KEYWORDS:
Tolperisone Hydrochloride; Diclofenac Sodium; UV spectrophotometric method; Simultaneous Estimation, first order derivative method.
Cite:
Bhavarth Desai, Rishet Shukla, Shailesh Shah, Renu Chauhan, Dinesh Shah. Development and Validation of First Order UV-Spectrophotometric Method for Simultaneous Estimation of Tolperisone Hydrochloride and Diclofenac Sodium in Combined Tablet Dosage Forms. Asian J. Research Chem. 5(12): Dec., 2012; Page 1448-1451.
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