Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   215-217

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Simultaneous Estimation of Ranitidine and Drotaverine in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method



Address:   Rajesh K. Patel1*, Ravi N. Patel1, Dr. Ashok L. Ganure1, Dr. Laxmanbhai J. Patel2
1Department of Pharma. Analysis, K.J. College of Pharmacy, Vadasma-382708, 2Department of Pharma. Analysis, Shree S.K. Patel College of Pharmaceutical Education and Research, Mehsana, Gujarat
*Corresponding Author
DOI No:

ABSTRACT:
A Derivative Spectrophotometric method has been developed for simultaneous estimation of Ranitidine and Drotaverine in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 322 nm (?max for Ranitidine) and 306.5 nm (?max for Drotaverine). The linearity lies between 5-60µg/ml for Ranitidine and 4-20µg/ml for Drotaverine. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Ranitidine and Drotaverine in combined pharmaceutical dosage form.
KEYWORDS:
Simultaneous, Derivative Spectrophotometric, Ranitidine, Drotaverine, %RSD.
Cite:
Rajesh K. Patel, Ravi N. Patel, Dr. Ashok L. Ganure, Dr. Laxmanbhai J. Patel. Simultaneous Estimation of Ranitidine and Drotaverine in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method. Asian J. Research Chem. 5(2): February 2012; Page 215-217.
[View HTML]      [View PDF]



Visitor's No. :   113005