Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   253-258

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

Synthon Approach in Designing Organic Synthesis: A Case Study of Rational Synthesis Design of a Potent Antidiabetic Agent “Rosiglitazone.”



Address:   Chittaranjan Bhanja1*, Seetaram Mohapatra2
1Department of Chemistry, Upendra Nath (Degree) College, Nalagaja, Mayurbhanj-757073, Odisha, India.
2Department of Chemistry, Ravenshaw University, Cuttack-753003, Odisha, India.
*Corresponding Author
DOI No:

ABSTRACT:
Synthon approach advocated by Prof. E. J. Corey of Harvard University has emerged as a powerful analytical tool of design synthetic routes for the preparation of an organic compound of any interest from readily available starting materials. This approach plays a vital role in the synthesis of medicinal compounds/drugs which is a part and parcel of modern drug discovery process. Taking the privilege of this approach, a good number of synthesis schemes has been proposed for a potent anti-diabetic agent “rosiglitazone” keeping an overview on the works published in both journals and patent literatures. The proposed synthesis planning being a theoretical investigation, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which is cost-effective, safe, and easy to carry out and produces maximum yield in a short reaction time.
KEYWORDS:
Anti-diabetic agent, Drug synthesis, Synthon approach, Retrosynthetic analysis, Rosiglitazone.
Cite:
Chittaranjan Bhanja, Seetaram Mohapatra. Synthon Approach in Designing Organic Synthesis: A Case Study of Rational Synthesis Design of a Potent Antidiabetic Agent “Rosiglitazone. Asian J. Research Chem. 5(2): February 2012; Page 253-258.
[View HTML]      [View PDF]



Visitor's No. :   106632