Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   265-269

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

In vitro pharmacological activity of the whole plant Naregamia alata



Address:   Sonu Jacob1, Anil John J.2, Leena Thomas1, Sabulal B.2
1Dept. of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, AIMS Health Science Campus, Ponekkara (PO), Kochi, Kerala, India.
2Dept. of Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Pacha-Palode, Karimancode (PO), Thiruvananthapuram, Kerala, India.
*Corresponding Author
DOI No:

ABSTRACT:
Naregamia alata (Meliaceae) has been used in traditional medicines in India and elsewhere in the treatment of rheumatism, itch, malarial and chronic fevers, wounds, anaemia, enlarged spleen, ulcers, vitiated conditions of pitta and vata, halitosis, cough, asthma, splenomegaly, scabies, pruritis, dysentery, dyspepsia and catarrh. The in vitro antioxidant assay of the methanol extract was done by DPPH radical scavenging assay and showed moderate activity. Reducing power assay and Super oxide radical scavenging also showed moderate activity. IC50 Values of DPPH Radical Scavenging and Super oxide radical scavenging are compared. Antibacterial activity of the Pet.Ether, Chloroform and Methanol extracts against Gram positive and Gram negative bacteria were done using disc diffusion method. The chloroform extract showed remarkable activity against the tested organisms, while the others showed only moderate activity. Antifungal activity also done and Pet.ether extract having highest activity than the others.
KEYWORDS:
Naregamia alata, Meliaceae, Antioxidant activity, Antibacterial activity, Antifungal activity.
Cite:
Sonu Jacob, Anil John J., Leena Thomas, Sabulal B.. In vitro pharmacological activity of the whole plant Naregamia alata. Asian J. Research Chem. 5(2): February 2012; Page 265-269.
[View HTML]      [View PDF]



Visitor's No. :   126925