Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   275-278

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Two Spectrophotometric Methods for the Simultaneous Estimation of Rosuvastatin Calcium and Aspirin in their Combined Dosage Form



Address:   Godavariya Vijay D.*, Prajapati P.B. , Bodiwala K.B. and Shah S. A.
Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, Gujarat, India- 394 350
*Corresponding Author
DOI No:

ABSTRACT:
Two spectrophotometric methods for simultaneous estimation of Rosuvastatin calcium (RSV) and Aspirin (ASP) in combined dosage form have been developed. The first method is Q-analysis method (Q-absorbance ratio), which involves the formation of Q-absorbance equation at 265.0 nm (Iso-absorptive point) and 276.4 nm (?-max of aspirin). In this method the linearity was evaluated over the concentration range of 5-25µg/ml and 25-125µg/ml for rosuvastatin and aspirin respectively. The second method is derivative spectrophotometric method which involves the absorbance of the combined dosage form solution at 243.20 nm (ZCP of RSV) and 256 nm (ZCP of ASP). The linearity was observed in the concentration range of 5-25µg/ml for RSV and 25-125µg/ml for ASP. Accuracy of the methods were assessed by recovery studies and was found to be 99.50±0.919 to101.10±0.883 and 99.04±0.993 to 102.33±0.237 for Q-absorbance ratio method and 100.13±0.500 to 101.07±0.070 and 99.60±0.771 to 101.33±0.564 for derivative spectrophotometric method for RSV and ASP respectively. The proposed methods are simple, accurate, precise, rapid and cost effective. Therefore the proposed methods can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.
KEYWORDS:
Q-analysis method, Derivative spectrophotometric method. Iso-absorptive point, Rosuvastatin and Aspirin.
Cite:
Godavariya Vijay D., Prajapati P.B. , Bodiwala K.B., Shah S. A.. Development and Validation of Two Spectrophotometric Methods for the Simultaneous Estimation of Rosuvastatin Calcium and Aspirin in their Combined Dosage Form. Asian J. Research Chem. 5(2): February 2012; Page 275-278.
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