Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   279-281

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric determination of cabergoline in tablet dosage forms.



Address:   C. Rambabu1, Dr. C.A. Jyothirmayee2, K. Naga Raju3*
1Professor, Department of Chemistry, A. N. U. PG Centre Nuzvid-521201,
2Reader and head, Department of Chemistry, St. Theresa’s College for Women, Eluru-534003,
3Assistant Professor, Dept. of Pharmaceutical Analysis, Sir. C.R.R. College of Pharmaceutical Sciences, Eluru,
*Corresponding Author
DOI No:

ABSTRACT:
New, simple, selective and accurate spectrophotometric methods are described in the present work for the determination of cabergoline in the pure samples and pharmaceutical formulations. Both the methods are based on the ion association complex formation of cabergoline with alizarin red S(ARS) and naphthol blue black(NBB) to form yellow and purple colored chromogen with absorption maxima at 425nm and 585nm respectively. Beer's law is obeyed in the concentration ranges of 1-6 µg/ml and 2-12 µg/ml respectively. The results of analysis for the two methods have been validated statistically and by recovery studies. The methods are extended to pharmaceutical formulations
KEYWORDS:
ARS, NBB, and Cabergoline.
Cite:
C. Rambabu, C.A. Jyothirmayee, K. Naga Raju. Spectrophotometric determination of cabergoline in tablet dosage forms. Asian J. Research Chem. 5(2): February 2012; Page 279-281.
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