Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  2

Year :  2012

Pages :   282-285

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Nebivolol Hydrochloride and Indapamide in Tablet Dosage Form



Address:   Rajanikant M. Chodavadia*, Bhavin P. Marolia, Shailesh A. Shah, Girish C. Dudhat
Department of Quality Assurance, Maliba Pharmacy College, Bardoli-Mahuva Road, Tarsadi, Dist. Surat, 394 350, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
Accurate, precise, rapid and economical spectrophotometric method was developed for the estimation of Indapamide and Nebivolol in bulk dosage form. In first order derivative spectrophotometry, wavelengths selected for quantitation were 271.40nm for Nebivolol (zero crossing point for indapamide) and 244.90nm for Indapamide (zero crossing point for nebivolol). The method was validated as per ICH guideline. In this method the linearity was observed in the concentration range of 6-30µg/ml for Nebivolol and 2-10µg/ml for Indapamide. The accuracy and precision were determined and found to comply with ICH guidelines. The proposed method was successfully applied for the simultaneous estimation of both drugs in commercial tablet preparation.
KEYWORDS:
Indapamide, Nebivolol, Derivative spectrophotometry.
Cite:
Rajanikant M. Chodavadia, Bhavin P. Marolia, Shailesh A. Shah, Girish C. Dudhat. First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Nebivolol Hydrochloride and Indapamide in Tablet Dosage Form. Asian J. Research Chem. 5(2): February 2012; Page 282-285.
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