Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  3

Year :  2012

Pages :   405-408

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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An Effective RP-HPLC Method for the Simultaneous Determination of Atenolol and Indapamide in Marketed Tablet Formulation (ATEN-D)



Address:   Naveen Kadian*, Meenaxi Maste, A. R. Bhat
Department of Pharmaceutical Chemistry, KLEU’s College of Pharmacy, Belgaum, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
In the present study a simple, sensitive, accurate and effective Reverse Phase High-Performance liquid chromatographic (RP- HPLC) method was developed for the determination of Atenolol and Indapamide simultaneously in the tablets. The analysis was resolved by using a mobile phase methanol: water (60:40) with 0.1%v/v of Ammonium Hydroxide, at a flow rate of 1ml/min on an isocratic HPLC system consisting of SPD-20 A/20AV UV-VIS detector using C18 column at a wavelength of 260 nm. The retention time was found to be 7.5 and 8.9 min respectively. Linearity was established for Atenolol and Indapamide in the range of 4.5-500 µg/ml and 0.225-25 µg/ml respectively.
KEYWORDS:
Atenolol, Indapamide, RP-HPLC.
Cite:
Naveen Kadian, Meenaxi Maste, A. R. Bhat. An Effective RP-HPLC Method for the Simultaneous Determination of Atenolol and Indapamide in Marketed Tablet Formulation (ATEN-D). Asian J. Research Chem. 5(3): March 2012; Page 405-408.
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