Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  3

Year :  2012

Pages :   422-424

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and UV- spectrophotometric Methods for Quantitative Estimation of Tenofovir disproxil fumarate in Bulk and Pharmaceutical Dosage Form



Address:   Prof. D. Srinivasa Rao, M. Balaji, S. Haranadh Reddy, S. Ramu, K. Kondala Rao, G. Rama Krishna
K.C. Reddy Institute of Pharmaceutical Sciences, Jangamguntlapalem, Medikonduru, Guntur Dist.
*Corresponding Author
DOI No:

ABSTRACT:
First-order UV-Spectrophotometric method have been developed and validated for the estimation of Tenofovir disproxil fumarate in bulk and its tablet formulations. The solutions of standard and sample were prepared in water. Tenofovir disproxil fumarate was estimated at 248 nm for the First order UV-Spectrophotometric method. Beer’s law was obeyed in the concentration range of 5-30 µg/ml with r2 value 0.999 for First order. These methods were tested and validated for various parameters according to ICH guidelines. The proposed methods were successfully applied for the determination of Tenofovir disproxil fumarate in tablet formulations.
KEYWORDS:
Tenofovir disprixil fumarate, Method validation, Derivative UV-Spectrophotometric Methods.
Cite:
D. Srinivasa Rao, M. Balaji, S. Haranadh Reddy, S. Ramu, K. Kondala Rao, G. Rama Krishna. Development and UV- spectrophotometric Methods for Quantitative Estimation of Tenofovir disproxil fumarate in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 5(3): March 2012; Page 422-424.
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