Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   504-509

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Allready Registrered
Click to Login

Salicylaldehyde Schiff bases Bioactivity Prediction by Insilico Approach

Address:   Valli G., Ramu K., Mareeswari P.
Department of Chemistry, SFR College for women, Sivakasi.
*Corresponding Author

Our study focuses the prediction of the bioactivity of Salicylaldehyde Schiff bases by computational method using PASS (online software for bioactivity prediction) by knowing the importance of Schiff bases derived from salicylaldehyde with various amines. Thirteen Schiff bases selected for our work. PASS prediction result showed that salicylaldehyde o-phenylenediamine Schiff bases possessed higher laccase inhibitor (91.6% )activity and 3-hydroxybenzoate 4-monooxygenase inhibitor(88%) activities. salicylaldehyde luicine Schiff base possessed antiseborrheic(86.1%), Pro-opio melanocortin converting enzyme inhibitor(86.5%) and protein-glutamate methyl esterase activity(85.2%). salicylaldehyde Schiff bases derived from 2-aminopyridine, ethylenediamine, Glycine, 2,4-dinitrophenylhydrazine, 4-aminobenzene sulphonamide and methionine were found to have Glutathione thiolesterase inhibitor(86.3%), Glucose oxidase inhibitor (86.1%), Monophenol monooxygenase inhibitor (86.5%) , Cis-1,2-dihydro-1,2dihydroxy naphthalene dehydrogenase inhibitor (89.5%),Anthranilate 3-monooxygenase (deaminating)Inhibitor(88.7%) ,Corticosteroid side-chain-isomerase inhibitor (88.7%), Sulfite reductase inhibitor(86.1%), Pullulanase inhibitor (85.8%) and 3-Phytase inhibitor(85.4%). Aryl acetonitrilase inhibitor (85.2%), Arylformamidase inhibitor (91.2%), Phenylalanine (histidine) transaminase inhibitor (89.4%) and L-3-cyanoalanine synthase inhibitor (88.9%) activities. They also found to act as Dopamine D4 agonist (89.5%) and Antiprotozoal (Toxoplasma) (87%) compared to other Schiff bases.
o-phenylenediamine, Luicine, Laccase , salicylaldehyde, PASS.
Valli G., Ramu K., Mareeswari P.. Salicylaldehyde Schiff bases Bioactivity Prediction by Insilico Approach. Asian J. Research Chem. 5(4): April 2012; Page 504-509.
[View HTML]      [View PDF]

Visitor's No. :   92728