Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  4

Year :  2012

Pages :   483-491

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique



Address:   Ahmed Samir1, Nagia El-Megrab1, Hanaa A. Fattah1, Waleed Barakat2
Departments of 1Pharmaceutics, 2Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt.
*Corresponding Author
DOI No:

ABSTRACT:
The objective of present was to improve the solubility of Clonazepam (CZP), poorly water soluble drug, by solid dispersion technique using Polyethylene glycol 6000 (PEG 6000) and Urea (UR) as carriers. The Solid dispersion was prepared by physical mixing and solvent evaporation method. The interaction of the Clonazepam with PEG 6000 and UR was evaluated by the Fourier transform infrared (FTIR) spectroscopy; Differential scanning Calorimetry (DSC) and X-ray diffraction patterns (XRD). The results from the FTIR and XRD analyses showed that Solid dispersion might exist in the amorphous form. A DSC result showed that the sharp melting point was completely disappeared suggesting that the CZP molecularly dispersed in an amorphous form. Dissolution studies indicate that dissolution rate was remarkably increased in Solid dispersion as compared to the physical mixture and drug alone. Also the pharmacological studies of the selected formulations [(1:3 CZP : PEG 6000) and (1:2 CZP : Urea)] were performed. In conclusion PEG 6000 and UR can be a well utilized to increase the solubility of poorly water soluble drugs.
KEYWORDS:
Clonazepam, solid dispersion, Polyethylene glycol 6000, Urea.
Cite:
Ahmed Samir, Nagia El-Megrab, Hanaa A. Fattah, Waleed Barakat. Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique. Asian J. Research Chem. 5(4): April 2012; Page 483-491.
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