Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   668-677

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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In vitro Interaction of Fexofenadine with H2 Receptor Antagonist



Address:   Hina Shahnaz1*, M. Saeed Arayne2, Najma Sultana2 and Amir Haider2
1Department of Chemistry, University of Karachi, Karachi.
2Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi.
*Corresponding Author
DOI No:

ABSTRACT:
Fexofenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. The in vitro availability of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine) was studied on a BP 2005 dissolution test apparatus to observe the kinetics and energies of fexofenadine in the presence of H2-receptor antagonist (cimetidine, ranitidine and famotidine). These studies were carried out in buffers of pH 2, 4 (simulated gastric juice), 7.4 (blood pH) and 9 (simulated intestinal juice) at 37°C and at elevated temperatures. These studies showed that all H2-receptor antagonist (cimetidine, ranitidine and famotidine) interact to fexofenadine. Moreover, these interactions were not temperature dependent but pH dependent.
KEYWORDS:
Fexofenadine, H1-receptor antagonist, in vitro, H2-receptor antagonist, interactions.
Cite:
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro Interaction of Fexofenadine with H2 Receptor Antagonist. Asian J. Research Chem. 5(5): May 2012; Page 668-677.
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