Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   678-680

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Tropicamide and Phenylepherin Hydrochloride in Ophthalmic Dosage Form



Address:   Tarkase K.N.*, Hapse S.A.*, Kadaskar P.T., Shirsath A.S., Aher N.G., Kothule M.B.
Department of Quality Assurance Technique, Padmashree Dr. Vithalrao Vikhe Patil College of Pharmacy, Ahmednagar. Maharashtra. 414111.
*Corresponding Author
DOI No:

ABSTRACT:
A spectrophotometric method for the simultaneous estimation of Tropicamide (TPC) and Phenylepherin hydrochloride (PHE) in their combined dosage form have been developed and validated for linearity, accuracy, precision, ruggedness and repeatability. The wavelength selected to develop the equation were 253 nm and 235 nm in distilled water, For TPC and PHE. Both drugs show linearity in the concentration range of 4-20µg/ml for TPC and 5-125µg/ml for PHE. The results have been statistically validated and were found to be simple, rapid, accurate, precise and reproducible.
KEYWORDS:
Tropicamide, phenylepherin hydrochloride, Validation.
Cite:
Tarkase K.N., Hapse S.A., Kadaskar P.T., Shirsath A.S., Aher N.G., Kothule M.B.. Simultaneous Spectrophotometric Estimation of Tropicamide and Phenylepherin Hydrochloride in Ophthalmic Dosage Form. Asian J. Research Chem. 5(5): May 2012; Page 678-680.
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