Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   687-696

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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In vitro drug interaction studies of Fexofenadine with Enoxacin, Levofloxacin and Sparfloxacin

Address:   Hina Shahnaz1*, M. Saeed Arayne2, Najma Sultana2 and Amir Haider2
1Department of Chemistry, University of Karachi, Karachi.
2Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi.
*Corresponding Author

An in vitro availability of fexofenadine in the presence of quinolones (enoxacin, levofloxacin and sparfloxacin) was carried out on a BP 2005 dissolution test apparatus. Fexofenadine second generation non sedative H1 receptor antagonist is an active carboxylic acid metabolite of terfenadine. These reactions were performed at different pH environment (2, 4, 7.4 and 9) at 37 ºC human physiological temperature, at 48 and 60ºC. By the alteration of Beer’s law through simultaneous equation of two components system the reactions were studied. The ultraviolet method is simple and quite accurate. The results from interaction and kinetic studies reveal that these drug interactions are not temperature dependant, but pH dependant and occur more frequently in more acidic or basic medium.
Fexofenadine, terfenadine, in-vitro, quinolone, UV spectrophotometer, Beer’s law, dissolution test apparatus, interactions.
Hina Shahnaz, M. Saeed Arayne, Najma Sultana, Amir Haider. In vitro drug interaction studies of Fexofenadine with Enoxacin, Levofloxacin and Sparfloxacin. Asian J. Research Chem. 5(5): May 2012; Page 687-696.
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