Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  5

Year :  2012

Pages :   722-724

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Validated Non-aqueous Potentiometric Titration Method for the Quantitative Determination of Lafutadine from Pharmaceutical Preparation



Address:   Rele Rajan V.*, Gurav Pankaj J., Sawant Swapnil A.
Department of Chemistry, D.G. Ruparel College, Mahim, Mumbai 400016.
*Corresponding Author
DOI No:

ABSTRACT:
A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of lafutadine from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.99) between 20 % to 100 % of 100 mg of drug substance weight. The percentage recovery of lafutadine in the optimized method was between 99.878 to 101.315 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.
KEYWORDS:
Lafutadine , Perchloric acid , Potassium hydrogen phthalate , Glacial acetic acid.
Cite:
Rele Rajan V., Gurav Pankaj J., Sawant Swapnil A.. A Validated Non-aqueous Potentiometric Titration Method for the Quantitative Determination of Lafutadine from Pharmaceutical Preparation. Asian J. Research Chem. 5(6): June, 2012; Page 722-724.
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