Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   748-752

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Validated Simple and Affordable Visible Spectrophotometric Methods Development for the Assay of Almotriptan malate in Bulk and Pharmaceutical Preparations



Address:   U. Viplava Prasad1, M. Syam Bab1*, B. Kalyana Ramu2
1Department of Organic Chemistry and Analysis of Foods Drugs and water Laboratories, AU College of Science and Technology, Andhra University, Visakhapatnam -530003 Andhra Pradesh (India)
2Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, sensitive and affordable visible spectrophotometric methods (M1 and M2) have been developed for the estimation of Almotriptan malate (AM) in bulk and dosage forms. Method M1 involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to form colored chromogen with an absorption maximum of 560 nm and the method M2 is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 620 nm. Beer’s law obeyed in the concentration range of 8-24µg/ml for method M1 and 20-60 µg/ml for method M2. Axert tablets were analyzed and the results are statistically compared with those obtained by the reference UV method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the almotriptan malate in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.
KEYWORDS:
Anti-migraine, Assay, Acetic anhydride, Citric acid, Cobalt thiocyanate, Beer’s Law, Tablets.
Cite:
U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu. Validated Simple and Affordable Visible Spectrophotometric Methods Development for the Assay of Almotriptan malate in Bulk and Pharmaceutical Preparations. Asian J. Research Chem. 5(6): June, 2012; Page 748-752.
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