Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   767-773

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Kinetic Spectrophotometric Determination of Antifungal Drugs in Pharmaceuticals

Address:   B.S. Virupaxappa1*, R.M. Kulkarni2, K.H. Shivaprasad1 and Latha M.S.3
1Department of Chemistry, VSK University, Bellary, Karnataka, (INDIA)
2Department of Chemistry, Gogte Institute of Technology, Udyambag, Belgaum, Karnataka, (INDIA)
3Department of Chemistry, GM Institute of Technology, Davangere, Karnataka, (INDIA)
*Corresponding Author

Simple and sensitive kinetic spectrophotometric methods have been developed and validated for the determination of Antifungal drugs, Flucanazole and Ketoconazole in their pharmaceutical dosage forms. The method is based on the oxidation of Flucanazole and Ketoconazole with alkaline and acidic potassium permanganate respectively. In alkaline medium permanganate (Mn+7) oxidizes Flucanazole and undergoes one electron reduction to give a green colored manganate ions (Mn+6) which has wavelength maximum at 610 nm, and unreacted permanganate at 526 nm. In acidic medium the course of the reaction was conveniently followed by measuring the absorbance of permanganate at 526 nm, as the permanganate undergoes five electrons reduction to give divalent manganese ions (Mn+2) . The calibration graphs are linear in the concentration ranges from 30.8–308 µgmL-1 and 20.6 – 206 µgmL-1 using the Fixed time methods and Rate constant methods respectively. The proposed method has a great value in its application to the analysis of Flucanazole and Ketoconazole in quality control laboratories.
Flucanazole, Ketoconazole, Kinetic spectrophotometry, Fixed time method, Rate constant method.
B.S. Virupaxappa, R.M. Kulkarni, K.H. Shivaprasad, Latha M.S.. Kinetic Spectrophotometric Determination of Antifungal Drugs in Pharmaceuticals. Asian J. Research Chem. 5(6): June, 2012; Page 767-773.
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