Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   787-790

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Spectrophotometric Estimation of Omeprazole and Ondansetron Hydrochloride by First Order Derivative Spectroscopy Method in Combined Dosage Form.



Address:   Reshma Kolte*, Vrushali Tambe, Vijaya Vichare and Manaswi Patil
Modern College of Pharmacy (for Ladies), Dehu-Alandi Road, Borhadewadi, Moshi, Pune-412105.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, accurate and reproducible first order spectrophotometric method, requiring no prior separation, has been developed and validated for the estimation of Omeprazole (OME) and Ondansetron (OND) in combined dosage form. First order derivative spectroscopy method was adopted to eliminate spectral interference. It was developed using wavelengths 309.8 nm and 275 nm as zero crossing points for estimation of OME and OND respectively. The method obeys Beer’s Law in concentration range of 5-100µg/ml. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Omeprazole, Ondansetron, First Order Derivative Spectroscopy, Simultaneous spectrophotometry.
Cite:
Reshma Kolte, Vrushali Tambe, Vijaya Vichare, Manaswi Patil. Simultaneous Spectrophotometric Estimation of Omeprazole and Ondansetron Hydrochloride by First Order Derivative Spectroscopy Method in Combined Dosage Form. Asian J. Research Chem. 5(6): June, 2012; Page 787-790.
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