Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   704-711

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Green Synthesis of Novel Heterocycles Carrying Triazole Derivatives of Dihydropyrimidine



Address:   Dawle J. K. 1*, Mathapati S. R.2, Bondge A. S.3, Momin K. I.4
1Research Laboratory of Pure and Applied Chemistry, Maharashtra Mahavidyalaya, Nilanga.
2Asst. Prof. Department of Chemistry, Shri Madhavrao Patil Mahavidyalaya, Murum.
3Asst. Prof. Department of Chemistry, Shivneri Mahavidyalaya, Shirur Anatpal.
4Asst. Prof. Department of Chemistry, Rajarshri Shahu, Mahavidyalaya, Latur.
*Corresponding Author
DOI No:

ABSTRACT:
The novel heterocycles, Ethyl -6- methyl- 2- oxo- 4- (2- phenyl -1,2,3-triazol-4-yl) - 3,4 dihydropyrimidine-5- carboxylate (4) have been synthesized from 1,3-dicarbonyl compounds, appropriate aldehyde and urea or thiourea under green method. 6– Methyl – 4 –(2- phenyl -1,2,3-triazol-4-yl) –5-(5-substituted phenyl -1, 3, 4–oxadiazol -2- yl) -3, 4-dihydropyrimidine-2(1H)-one (6 a-g) have been synthesized from comp. (4) using hydrazine hydrate, substituted benzoic acid, phosphorous oxychloride by microwave irradiation reported in literature. Above synthesized heterocycles 6 a-g irradiated under microwave with hydrazine hydrate to get amino triazole derivatives of dihydropyrimidine 7 a-g. The structures of newly synthesized compounds have been confirmed by IR and 1H NMR spectra.
KEYWORDS:
Dihydropyrimidines, Oxadiazole, Triazole, hydrazine hydrate, Green Method.
Cite:
Dawle J. K. , Mathapati S. R., Bondge A. S., Momin K. I.. Green Synthesis of Novel Heterocycles Carrying Triazole Derivatives of Dihydropyrimidine. Asian J. Research Chem. 5(6): June, 2012; Page 707-711.
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