Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  6

Year :  2012

Pages :   718-721

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Spectrophotometric characterization of propranol-hydroxypropyl--cyclodextrin inclusion complex

Address:   Inas EL Hassan1, Ahmad Allouch1, Adib Abou Dalle1, Mohammad Tabcheh1, Hanna El-Nakat2, Fawaz El Omar1*
1Laboratory of Applied Chemistry (LAC), Faculty of Science III, Lebanese University, P.O. Box 826, Tripoli, Lebanon
2Department of Chemistry, Faculty of Science, University of Balamand, P.O. Box 100, Tripoli, Lebanon
*Corresponding Author

Cyclodextrins (CD) are a group of natural products formed during bacterial digestion of starch. These cyclic oligosaccharides consist of (a-1,4)-linked a-D-glucopyranose units and contain a hydrophobic central cavity and a hydrophilic outer surface. Cyclodextrins are well known for their ability to interact with poorly-water soluble compounds to form inclusion complexes thus increasing their apparent solubilities. For this reason, the most important application of CD in pharmaceutical industry is to enhance drug solubility in aqueous solutions. Propranolol is a very important ß-blocker drug, mainly used in the treatment of hypertension and cardiac arrhythmias. In this paper, a simple and rapid spectrophotometric method has been investigated for the study of inclusion complex of propranolol with hydroxypropyl-ß-cyclodextrin (HP???CD). The stoichiometry of propranolol- HP???CD complex has been determined by continuous variation (Job's plot) method and the overall association constant was determined by using Scott's method.
Inclusion complexes, Cyclodextrin, Chirality, HPLC Chromatography, Chiral selectors.
Inas EL Hassan, Ahmad Allouch, Adib Abou Dalle, Mohammad Tabcheh, Hanna El-Nakat, Fawaz El Omar. Spectrophotometric characterization of propranol-hydroxypropyl--cyclodextrin inclusion complex. Asian J. Research Chem. 5(6): June, 2012; Page 718-721.
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