Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   875-881

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Impurity Profiling With Use of Hyphenated Techniques



Address:   Dwivedi Abha*, Kaushik Avinash, Sharma Ganesh N., Akhtar Javed
School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302017.
*Corresponding Author
DOI No:

ABSTRACT:
Impurity profiling is very important for the identification source, types, structure elucidation and quantitative determination of organic and inorganic impurities in the dosage form and bulk drugs. Presence of these impurities affects the pharmacological property, stability of the formulation. So with the increase demand of the purity of product number of analytical methods have been developed. Identification of the impurities are done by chromatographic, spectroscopic and with the hyphenated techniques. Hyphenated techniques are widely used in impurity profiling as it has revolutionized the impurity profiling by not only the separation but structural identification of the impurities. The hyphenated techniques which are widely used are LC-NMR, LC-MS-MS, GC-MS, and LC-FTIR etc.
KEYWORDS:
Impurity, Impurity Profiling, Hyphenated, Analytical Methods.
Cite:
Dwivedi Abha, Kaushik Avinash, Sharma Ganesh N., Akhtar Javed. Impurity Profiling With Use of Hyphenated Techniques. Asian J. Research Chem. 5(7): July, 2012; Page 875-881.
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