Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   893-895

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Pantoprazole and Diclofenac sodium in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method



Address:   Rajesh K. Patel1*, Ravi N. Patel1, Hitesh B. Patel1, Vinas A. Patel1, Dr. Ashok L. Ganure1, Dr. Laxmanbhai. J. Patel2
1Department of Pharmaceutical Analysis, K.J. College of Pharmacy, Vadasma-382708,
2Department of Pharmaceutical Analysis, Shree S.K. Patel College of Pharmaceutical Education and Research, Mehsana, Gujarat
*Corresponding Author
DOI No:

ABSTRACT:
A Derivative Spectrophotometric method has been developed for simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined Pharmaceutical dosage forms. Methanol was used as solvent. The method involves the measurement of absorbance at two wavelength 291 nm (?max for Pantoprazole) and 282 nm (?max for Diclofenac Sodium). The linearity lies between 5-25µg/ml for Pantoprazole and 10-50µg/ml for Diclofenac Sodium. The accuracy and precision of methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2%.The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Pantoprazole and Diclofenac Sodium in combined pharmaceutical dosage form.
KEYWORDS:
Simultaneous, Derivative Spectrophotometric, Pantoprazole, Diclofenac Sodium, %RSD.
Cite:
Rajesh K. Patel, Ravi N. Patel, Hitesh B. Patel, Vinas A. Patel, Ashok L. Ganure, Laxmanbhai. J. Patel. Simultaneous Estimation of Pantoprazole and Diclofenac sodium in Combined Pharmaceutical Dosage Form by Derivative Spectrophotometric Method. Asian J. Research Chem. 5(7): July, 2012; Page 893-895.
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