Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   896-898

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and evaluation of antimicrobial activity of some 5-[(5-substituted furan-2-yl) methylene]-(3H)-3-substituted benzyl-4-thioxo thiazolidine-2-one derivatives



Address:   Dahikar G.D.*, Ramteke A.N., Gadwe A.A., Yeole P.G.
Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha (M.S.) India. 442001
*Corresponding Author
DOI No:

ABSTRACT:
A series of thiazolidine-2, 4-dione was prepared as potential antimicrobial agents by conventional method. All the synthesised compounds have been screened for their antibacterial activity against S. aureus, E.coli and antifungal activity against C.albicans. The identification and characterization of the synthesised compounds were carried out by melting point, thin layer chromatography, 1H NMR, IR, and MASS spectra. Among the synthesised compounds, compound (IIIb and IIIf) showed better antimicrobial activity as compared to other analogues (IIIa, IIIc, IIId and IIIe) against S.aureus, and E.coli and C.abicans.The antibacterial and antifungal activities of the compounds were compared with the standard drugs like Ciprofloxacin and Miconazole respectively.
KEYWORDS:
Thiazolidine - 2, 4-dione; In vitro MIC assay; antimicrobial activity; S.aureus, E.coli, C.abicans.
Cite:
Dahikar G.D., Ramteke A.N., Gadwe A.A., Yeole P.G.. Synthesis and evaluation of antimicrobial activity of some 5-[(5-substituted furan-2-yl) methylene]-(3H)-3-substituted benzyl-4-thioxo thiazolidine-2-one derivatives. Asian J. Research Chem. 5(7): July, 2012; Page 896-898.
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