Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   901-906

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Biological Evaluation of Some Novel Substituted Thiazolidine and Pyrazolone Derivatives



Address:   Jignesh B. Patel* and Dr. Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India
*Corresponding Author
DOI No:

ABSTRACT:
In the present investigation, our aim of synthesis is to find a molecule which resists the anti inflammatory and microbial infection. So, thiazolidine and its derivatives and pyrazolone and their condensed derivatives was prepared and tested the Anti inflammatory activities of synthesized compound by rat paw edema method using phenylbutazone as a standard and in-vitro antibacterial activity of synthesized compound against Gram positive and Gram negative microorganisms (Staphylococcus aureus MTCC 96 and Escherichia coli MTCC 521) tested by filter paper disk method using Ofloxacin as a standard drug. All the compounds were characterized by IR, Mass and NMR. All Compounds possess a molecular ion M+ and M+2 peaks due to presence of chlorine. In the 1H NMR spectra of 7a compound, signal for OCH3 proton was observed with value 3.73 and CH3 proton was observed with value 1.71. In anti inflammatory activities Compound 7b found to have better anti-inflammatory activity while Compounds 7a, 7e and 7f showed this activity but less potent than compound 7b and phenylbutazone and Compound 7c and 7d were found to be least potent among the series. In antibacterial screening all compounds found to have more activity against gram negative bacteria E.coli. Compound 7b, 7c and 7d found to have better antibacterial activity against gram negative bacteria E.coli and compounds 7a, 7e and 7f shown activity against E.coli, but less potent than compound 7b,7c, 7d and Ofloxacin.
KEYWORDS:
Thiazolidine, Pyrazolone, Antibacterial Activity.
Cite:
Jignesh B. Patel, Dhrubo Jyoti Sen. Synthesis and Biological Evaluation of Some Novel Substituted Thiazolidine and Pyrazolone Derivatives. Asian J. Research Chem. 5(7): July, 2012; Page 901-906.
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