Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   913-917

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of 1-Heterocyclicaminomethyl-3-(4′-arylamino-3′-nitrozoylhydrazono)-2-indolinones: Search of some new antifilarial compounds–IV



Address:   B.N. Singh1*, Sachendra Kumar Mishra1, Meera Singh1, K.K. Ojha2 and Vivek Gupta3
1Chemistry Department, Sri Baldeo P.G. College Baragaon Varanasi, 221204 (U.P.) 2B.R.D. College, Deoriya
3S.V. College of Engineering and Technology, Muzaffar Nagar (UP)
*Corresponding Author
DOI No:

ABSTRACT:
Twelve 1-Heterocyclicaminomethyl-3-(4'-arylamino-3'-nitrozoylhydrazono)-2-indolinones (Via-VIl) were synthesized starting from 4-chloro-3-nitrobenzoic acid. All these compounds were subjected for antifilarial testing on cotton rats infected with L. Carinii. Compound VIj was found to be most active showing 79, 55.7 and 88.8% reduction in mf count on the day 8, 21 and 42 respectively.
KEYWORDS:
DEC, L. carinii, antifilarial activity.
Cite:
B.N. Singh, Sachendra Kumar Mishra, Meera Singh, K.K. Ojha, Vivek Gupta. Synthesis of 1-Heterocyclicaminomethyl-3-(4′-arylamino-3′-nitrozoylhydrazono)-2-indolinones: Search of some new antifilarial compounds–IV. Asian J. Research Chem. 5(7): July, 2012; Page 913-917.
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