Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   819-826

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Novel Substituted 3,4-Dihydroquinoxaline Derivatives as Antimicrobial Agents



Address:   Charoo S. Garg*, Jimit S. Patel and Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat
*Corresponding Author
DOI No:

ABSTRACT:
As a part of research project on the synthesis of number of substituted quinoxaline derivatives with electron donating as well as electron withdrawing groups has been done and evaluated them for antibacterial and antifungal activity. First of all different acetanilides were prepared by taking chloro acetyl chloride and substituted anilines. Then they were condensed with benzene diamine to form novel quinoxaline derivatives. Further quinoxalines were benzoylated by using 4-methoxy benzoyl chloride and 4-chloro benzoyl chloride. The purity of all compounds have been checked by the TLC monitoring and the confirmation of the structure was checked by different spectral analysis like UV, IR, Mass and NMR and evaluated for antibacterial agent using ciprofloxacin as a standard drug and for antifungal activity using clotrimazole as a standard drug.
KEYWORDS:
Quinoxaline derivatives, acetanilides, benzoylation, antifungal activity, antibacterial activity.
Cite:
Charoo S. Garg, Jimit S. Patel, Dhrubo Jyoti Sen. Synthesis of Novel Substituted 3,4-Dihydroquinoxaline Derivatives as Antimicrobial Agents. Asian J. Research Chem. 5(7): July, 2012; Page 819-826.
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