Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   925-931

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis Planning of a Potent Opioid Analgesic “Fentanyl”: A Retrosynthetic Approach



Address:   Chittaranjan Bhanja*, Satyaban Jena
Department of Chemistry, Utkal University, Bhubaneswar-751004, Odisha, India
*Corresponding Author
DOI No:

ABSTRACT:
Synthesis of pharmaceuticals/drugs for the process development, reaction condition optimization, and scale-up production is a part and parcel of modern drug discovery process. Design synthetic routes to pharmaceuticals/drugs via retrosynthetic analysis, coined by Nobel Laureate Prof. E.J. Corey of Harvard University, has emerged as a powerful analytical tool in synthetic organic/medicinal chemistry and most responsible for yielding material benefits to mankind. Keeping an overview on the works published in both journals and patent literatures a good number of synthesis schemes have been proposed in a novel way for a potent analgesic “fentanyl” from the results of its retrosynthetic analysis. In actual practice, generally that route is most feasible which is cost-effective, safe, produce maximum yield in a short reaction time under robust conditions.
KEYWORDS:
Analgesic, drug synthesis, fentanyl, retrosynthetic analysis, synthesis planning.
Cite:
Chittaranjan Bhanja, Satyaban Jena. Synthesis Planning of a Potent Opioid Analgesic “Fentanyl”: A Retrosynthetic Approach. Asian J. Research Chem. 5(7): July, 2012; Page 925-931.
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