Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  7

Year :  2012

Pages :   827-830

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Syntheses of Biologically active 1-[2-(1,3-Dimethyl-2,6-Dioxo-1,2,3,6-Tetrahydro-Purin-7-Yl)-Acetyl]-3-(Substituted Phenyl)-1H-Pyrazole-4-Carbaldehyde



Address:   Freddy H. Havaldar* and Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
1-[2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetyl]-3-(substituted phenyl)-1H-pyrazole-4-carbaldehydes (4a-e) have been synthesized by the cyclisation of (1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid [1-(substituted phenyl)-ethylidene]-hydrazides (3a-e) with phosphorous oxychloride in N,N-dimethylformamide. The pyrazoles have been characterized on the basis of analytical and spectral data and screened for biological activity.
KEYWORDS:
Synthesis, Pyrazoles, Antibacterial and antifungal activity.
Cite:
Freddy H. Havaldar, Azadkumar S. Sharma. Syntheses of Biologically active 1-[2-(1,3-Dimethyl-2,6-Dioxo-1,2,3,6-Tetrahydro-Purin-7-Yl)-Acetyl]-3-(Substituted Phenyl)-1H-Pyrazole-4-Carbaldehyde. Asian J. Research Chem. 5(7): July, 2012; Page 827-830.
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