Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1013-1016

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis of Flouro cinnoline(2,3-d)pyrimidine compound for antibacterial activity

Address:   Shashikant B. Bhot1, L.V.G. Nargund1*, Shachindra L. Nargund2
1Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreya Nagar, II Main,100 Ft Ring road, BSK II stage, Bangalore- 560085 (India).
2Department of Chemistry, Texas State University, San Micro USA.
*Corresponding Author

Fluoro cinnoline containing organic compounds forms a significant class of drugs which exhibit an array of biological activities ranging from antibacterial, anti-cancer, antihypertensive, The present work aimed to synthesize novel 4-fluoro-3-chloro cinnoline(2,3-d)pyrimidine derivative with a desire to obtain potent antibacterial activity. The synthesized derivatives are characterized by Melting point, TLC, IR and 1H NMR spectra. Among the all synthesized compounds 6a, 6b, 6c, 6d and 6e compounds tested showed good antibacterial activity. Anti-bacterial activity carried out in Bacillus subtilis and Escherichia coli compounds showed good activity against both Gram (+ve) and Gram (-ve) bacteria.
Fluoro cinnoline, anti-bacterial activity.
Shashikant B. Bhot, L.V.G. Nargund, Shachindra L. Nargund. Synthesis of Flouro cinnoline(2,3-d)pyrimidine compound for antibacterial activity. Asian J. Research Chem. 5(8): August, 2012; Page 1013-1016.
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