Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1017-1024

ISSN Print :  0974-4169

ISSN Online :  0974-4150


Registration

Allready Registrered
Click to Login

In vitro Interaction of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine



Address:   Amir Haider1*, Hina Shahnaz1, M. Saeed Arayne1 and Najma Sultana2
1Department of Environmental Studies, Sind Madressatul Islam (SMI) University, Karachi
2Department of Chemistry, University of Karachi, Karachi.
*Corresponding Author
DOI No:

ABSTRACT:
Amantadine was discovered in petroleum and name is derived from Greek name adamantinos (relating to steel or diamond), due to its diamond-like structure. The in vitro availability of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine was studied on a Compact Dissolution Test Apparatus-Type PTWS 310 manufactured by Pharmatest according to USP/EP. To observe the percentage availabilities of different classes of drugs in presence of amantadine were carried out at 37?C in simulated gastric juice as it was insoluble at all other pH levels found in human body. Results reflect the possible complexation of these drugs with amantadine. The in vitro availability of all drugs was found to be markedly retarded in the presence of amantadine.
KEYWORDS:
Amantadine, H1 and H2 receptor antagonist, ACE-inhibitors, ydrochlorothiazide, NSAIDs, Quinolones.
Cite:
Amir Haider, Hina Shahnaz, M. Saeed Arayne, Najma Sultana. In vitro Interaction of H1 and H2-receptor Antagonists, Cephalosporins, ACE-inhibitors, Hydrochlorothiazide, NSAIDs and Quinolones with Amantadine. Asian J. Research Chem. 5(8): August, 2012; Page 1017-1024.
[View HTML]      [View PDF]



Visitor's No. :   120757