Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   1038-1041

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Antibacterial Activity of 4-chloro-2-phenyl quinoline Derivatives



Address:   A. R. Chabukswar1*, B.S.Kuchekar1, P.D.Lokhande2, V.V. Chabukswar3, S.D. Tambe1, M.N. Mohokar1, B.D. Pagare1
1Department of Pharmaceutical Chemistry, MAEER’S Maharashtra Institute of Pharmacy, Kothrud, Pune-411038, Maharashtra, India.
2Center for Advanced Studies, Department of Chemistry, University of Pune, Pune - 411007, Maharashtra, India.
3Department of Chemistry, Nowrosjee Wadia College, Pune, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
A new series of 4-chloro-2-phenyl quinoline derivatives were synthesized and tested for antibacterial activity. O-nitro acetophenone and various substituted benzaldehyde were used to synthesize 4-chloro-2-phenyl quinoline derivatives. The structures of the newly synthesized derivatives have been confirmed on the basis of Spectral data. The synthesized compounds were screened for their antibacterial activity against strains viz. B. Subtilus, S. Aureus, P. aeurigenosa, E coli, S. typhi. The antibacterial activity study revealed that the derivatives Q3, Q5,Q6 and Q9 possess significant inhibitory activity against Gram negative and Gram positive bacteria including multidrug resistant strains of S. aureus (MSRA) while other derivatives shown moderate antibacterial activity. The MIC value of the active compounds was found to be 50 µg/ml. Ciprofloxacin was used as a standard drug.
KEYWORDS:
4-chloro-2-phenyl quinoline, O-nitro acetophenone, anti-bacterial activity, resistance, DNA Gyrase.
Cite:
A. R. Chabukswar, B.S.Kuchekar, P.D.Lokhande, V.V. Chabukswar, S.D. Tambe, M.N. Mohokar, B.D. Pagare. Synthesis and Antibacterial Activity of 4-chloro-2-phenyl quinoline Derivatives. Asian J. Research Chem. 5(8): August, 2012; Page 1038-1041.
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