Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   980-984

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Development and Validation of Stability Indicating RP-HPLC method for simultaneous estimation of Thiocholchicoside and Lornoxicam in Combined Tablet Dosage Form



Address:   Kinjal V. Vekariya1*, Bhavika Sailor1, Surya Thankaapaan1, Ashok Parmar1 and Rima N. Shah2
Smt. R.B. Patel Mahila Pharmacy College, Kailashnagar, Bhavnagar Highway Road Atkot, Ta.-Jasdan, Dist.-Rajkot. 360040, Gujarat, India
2Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, At and Post- Changa, Ta- Petlad, Dist. - Anand. 388421, Gujarat, India.
*Corresponding Author
DOI No:

ABSTRACT:
A simple, selective, accurate stability indicating Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method was developed and simultaneous estimation of Thiocholchicoside (THIO) and Lornoxicam (LORNO) in combined tablet dosage form. Chromatographic separation achieved isocratically on a C18 Column utilizing a mobile phase of Water (pH: 4): Methanol, (55:45 v/v) at a flow rate of 1.0 ml/min with UV detection at 382 nm. The retention time for THIO and LORNO was found to be 5.5 and 15.5 min, respectively. The method was also applied for the determination of THIO and LORNO in the presence of their degradation products formed under variety of stress conditions. Proposed method was validated for precision, accuracy, linearity range, robustness and ruggedness.
KEYWORDS:
Simultaneous Estimation; RP-HPLC; Lornoxicam, Thiocholchicoside, Validation, Stability indicating method.
Cite:
Kinjal V. Vekariya, Bhavika Sailor, Surya Thankaapaan, Ashok Parmar, Rima N. Shah. Development and Validation of Stability Indicating RP-HPLC method for simultaneous estimation of Thiocholchicoside and Lornoxicam in Combined Tablet Dosage Form. Asian J. Research Chem. 5(8): August, 2012; Page 980-984.
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