Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  8

Year :  2012

Pages :   996-997

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Hemozoin Induced Anemia and Dyserythropoisis: A Case Report



Address:   Dr. Sutrakar S.K.1, Dr. Singh U.R.2, Prabha Verma3, Dr. Priyanka Agrawal4, Dr. Damor Anil5
1Assistant Professor, Department of Pathology, S.S.Medical College & Asso.S.G.M. Hospital Rewa (M.P.)
2Associate Professor and Head, Department of Pathology, S.S.Medical College & Asso.S.G.M.Hospital Rewa (M.P.)
3Lecturer & Head, Department of Biochemistry, M.L.B. Medical College Jhansi (U.P.)
4Assistant Professor , Department of Pathology, S.S.Medical College & Asso.S.G.M.Hospital Rewa (M.P.)
5Resident Medical Officer, Department of Pathology, S.S.Medical College & Asso.S.G.M.Hospital Rewa (M.P.)
*Corresponding Author
DOI No:

ABSTRACT:
Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. It is shown by few authors that HZ-fed-monocytes, and 4-hydroxynonenal generated by various types of phagocytosed cells, inhibit progenitor cells, number, their growth and maturation. A variety of abnormalities in the number, morphology and function of blood and bone marrow cells may be found in Plasmodium falciparum. Severe anemia occurs in children with chronic falciparum malaria and low parasitaemia as well as in patients with complicated acute falciparum malaria with high parasitaemia. It has been proposed that the basis of severe malarial anemia, a major cause of morbidity and mortality in endemic areas, is multifactorial. Inappropriately low reticulocytosis is observed in malaria patients suggesting that insufficient erythropoiesis is a major factor. Plasmodium falciparum malaria on marrow examination showed myeloid hyperplasia, erythroid hyperplasia, megaloblastosis and hypoplasia in different proportions and in peripheral blood examination reveals macrocytosis, polychromasia, schistocytosis and presence of nucleated RBC along with pigment laden monocytes and Macrophages.
KEYWORDS:
Hemozoin, Bone marrow, Plasmodium falciparum, Parasitaemia, Dyserythropoiesis.
Cite:
Sutrakar S.K., Singh U.R., Prabha Verma, Priyanka Agrawal, Damor Anil. Hemozoin Induced Anemia and Dyserythropoisis: A Case Report. Asian J. Research Chem. 5(8): August, 2012; Page 996-997.
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