Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  9

Year :  2012

Pages :   1099-1103

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Synthesis and Characterization of Schiff bases of Chitosan for their Improved Mucoadhesion



Address:   Sachin R. Kumbhoje*, Zaki Husain J. Tamboli, Dr. John I. D’Souza
Department of Pharmaceutical Chemistry, Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Kolhapur, Maharashtra, India
Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warana-Nagar, Kolhapur, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
Chemically modified Chitosan are more or less similar to non modified Chitosan in the properties of biodegradability, non toxicity and the biocompatibility. The synthesized Schiff base derivatives bear a hydrophobic functionality at the amino terminal after a stepwise synthetic pathway of reductive amination. The bulkier hydrophobic moiety restrict to form intramolecular hydrogen bonding and then the intermolecular non covalent interactions like van der waals forces and hydrogen bonding of the functionalities with the mucosa avails the molecule with enhancing mucoadhesive effect. The mucoadhesive strength assessment provides a proof for the same. The spectroscopic data supports the structural elucidation.
KEYWORDS:
Schiff base, Chitosan, Mucoadhesion, Reductive amination.
Cite:
Sachin R. Kumbhoje, Zaki Husain J. Tamboli, Dr. John I. D’Souza. Synthesis and Characterization of Schiff bases of Chitosan for their Improved Mucoadhesion. Asian J. Research Chem. 5(9): September, 2012; Page 1099-1103.
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