Journal :   Asian Journal of Research in Chemistry

Volume No. :   5

Issue No. :  9

Year :  2012

Pages :   1195-1200

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Microwave Assisted Greener Synthesis of Indazoles via one pot two step Cyclization of Hydrazone Hydrate



Address:   Anuruddha Chabukswar1*, Bhanudas Kuchekar1, Pradeep Lokhande2, Mangesh Tryambake1, Jayprakash Sangshetti3, Bharat Pagare1, Pandurang kadam1.
1Department of Pharmaceutical Chemistry, MAEER’S Maharashtra Institute of Pharmacy, Kothrud, Pune-411038, Maharashtra, India.
2Center for Advanced Studies, Department of Chemistry, University of Pune, Pune - 411007, Maharashtra, India.
3Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
A highly efficient and eco-friendly one-pot microwave assisted method for synthesis of 1-H-indazole and 1-phenyl-1H-indazoles is developed. Microwave heating of salicylaldehyde and hydrazine hydrates yielded the aryl hydrazones which further cyclized to afford indazoles. Microwave assisted method results in good to excellent yields of indazoles than the conventional method.
KEYWORDS:
Hydrazine hydrate; hydrazone; Indazole; Microwave; Salicylaldehyde.
Cite:
Anuruddha Chabukswar, Bhanudas Kuchekar, Pradeep Lokhande, Mangesh Tryambake, Jayprakash Sangshetti, Bharat Pagare, Pandurang kadam. Microwave Assisted Greener Synthesis of Indazoles via one pot two step Cyclization of Hydrazone Hydrate. Asian J. Research Chem. 5(9): September, 2012; Page 1195-1200.
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