Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  10

Year :  2013

Pages :   879-887

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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A Review on 1,3-Thiazolidin-4-Ones

Address:   Kencha Swathi1*, Dr. M. Sreenivasulu2, T. Hari Narayana Reddy1, Y. Pradeep Kumar1, G. Mahaboob Basha1
1Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh.
2Head of the Department, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, New Boyanapalli, Kadapa (District), Andhra Pradesh.
*Corresponding Author

1,3-Thiazolidin-4-ones are important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. This review aims to review the work reported on the chemistry and biological activities of 1,3-thiazolidin-4-ones during the past few years. Since a decade extensive research work is undergoing on the thiazolidine ring. Researchers have developed number of new compounds related to1,3-thiazolidin-4-ones further they have screened them for various pharmacological activities to get a molecule with good pharmacological activities and with least adverse effects. The thiazolidine is not only synthetically important scaffold but also possesses a wide range of promising biological activities. Some thiazolidine derivatives have better activity than standard drug and could become a new drug for the market in future. This thiazolidine moiety and its derivatives has shown its importance as anti-microbial, anti-bacterial, anti-tubercular, anti-fungal, anti-inflammatory, analgesic, anti-cancer, anti-proliferative, anti- HIV, anti-retroviral,anti-yellowfevervirus,anti-diarrhoeal,anti-arrythmic agent, anti-convulsant, anti-oxidant, anti-malarial.
Thiazolidinone, biological activities, anti-microbial, anti-malarial, future aspect.
Kencha Swathi, M. Sreenivasulu, T. Hari Narayana Reddy, Y. Pradeep Kumar, G. Mahaboob Basha. A Review on 1,3-Thiazolidin-4-Ones. Asian J. Research Chem. 6(10): October 2013; Page 879-887.
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