Journal :   Asian Journal of Research in Chemistry

Volume No. :   6

Issue No. :  10

Year :  2013

Pages :   911-915

ISSN Print :  0974-4169

ISSN Online :  0974-4150


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Simultaneous Estimation of Cinitapride Hydrogen Tartrate (CNT) and Pantoprazole Sodium Sesquihydrate (PNP) in Capsule by Q-analysis UV- Spectrophotometric Method



Address:   N. R. Dighade1*, M. D. Shende1, A. V. Kasture2
1Adv. V. R. Manohar Institute of Diploma in Pharmacy, Wanadongri, Hingna Road, Nagpur–441110, INDIA.
2Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur, INDIA.
*Corresponding Author
DOI No:

ABSTRACT:
Cinitapride and Pantoprazole are available as capsule dosage forms in the ratio 1:13.33. A simple reproducible and efficient method for the simultaneous determination of cinitapride and pantoprazole in marketed formulation was developed. The proposed method is based on the Q-analysis UV-Spectrophotometric method. The absorbance maximum of cinitapride and pantoprazole were found to be 265.5 nm and 268 nm respectively in water. In Q-analysis, the isoabsorptive point for both the drugs was found at 236 nm. The linearity range lies between 5-30 µg/ml for cinitapride and pantoprazole at their respective wavelengths. Both the drugs obey Beers law. The recovery studies confirmed the accuracy of the proposed method.
KEYWORDS:
Pantoprazole, Cinitapride, Q-analysis, simultaneous estimation.
Cite:
N. R. Dighade, M. D. Shende, A. V. Kasture. Simultaneous Estimation of Cinitapride Hydrogen Tartrate (CNT) and Pantoprazole Sodium Sesquihydrate (PNP) in Capsule by Q-analysis UV- Spectrophotometric Method. Asian J. Research Chem. 6(10): October 2013; Page 911-915.
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